Experiment 1272631
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | PERFUSION |
| Organism | Empty organism |
| Citation | QUAN,SZ: XU,Y: JING,GW:. (1980). THE POTASSIUM-DEPLETING EFFECT OF GOSSYPOL ON ISOLATED RABBIT HEART AND ITS POSSIBLE MECHANISM.. () |
| Amount utilized | |
| Compound isolated | |
| Disease | BRIEF PERFUSION WITH LOCKE'S SOLUTION INDUCES A SIGNIFICANT LOSS OF THE POTASSIUM CONTENT OF THE LEFT VENTRICULAR MYOCARDIUM,TOGETHER WITH A DRASTIC DEPRESSION OF ITS CONTRACTILITY. THE ACTIONS WERE REVERSED WHEN MG ION(2-4 MEQ/L) WERE ADDED TO MEDIUM. IT IS SUGGESTED THAT THE POTASSIUM-DEPLETING(AND NEGATIVE INOTROPIC EFFECT OF GOSSYPOL ON THE ISOLATED HEART MIGHT BE THE CONSEQUENCE OF ITS POSSIBLE INHIBITORY ACTION OF NA-K-ATPASE, THUS INTERFERING IN THE ACTIVE K+ TRANSPORT. |
| Dose amount | 2.0 MG |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | RABBIT |
| Per unit | LITER |
| Dose expression | CONC USED |