Experiment 1272635

Details

PropertyValue
Pharmacology
Administration routeORAL
OrganismEmpty organism
CitationQIAN,SZ: HU,JH: HO,LX: SUN,MX: HUANG,YZ: FANG,JH:. (1980). THE FIRST CLINICAL TRIAL OF GOSSYPOL ON MALE ANTERFILITY.. ()
Amount utilized
Compound isolated
DiseaseTESTING ON 20 FERTILE MARRIED MEN,APPARENTLY HEALTHY,AT THE AGE OR 25-44.SPERMATOZOA WERE IMMOBILE AFTER 1-3 WEEKS OF DAILY DOSING. RECOVERY TO NORMAL SPERM COUNTS TOOK PLACE ABOUT 16 WEEKS AFTER GOSSYPOL WITHDRAWAL. SIDE EFFECTS WERE DECREASED APPETITE(7 CASES),FATIGUABILITY(5),DRYNESS OF MOUTH(5),DIARRHEA(4),INCREASED APPETITE(3),NAUSEA(3),SLEEPINESS(3),DIZZINESS(2),CONSTIPATION(1),VOMITING(1),AND EDEMA OF EYELIDS(1). SIDE EFFECTS WERE GENERALLY MILD AND REQUIRED NO TREATMENT. SERUM K+ CONCENTRATION WAS SLIGHTLY DEPRESSED IN 1 CASE(FROM 4.8 TO 3.5 MEQ/L. ROUTINE URINE EXAMINATION:PORTEIN INCREASE FROM A TRACE TO + IN 1 CASE,BUT SHORTLY RECOVERED. ECG,THYMOL TURBIDITY AND THYMOL FLOCCULATION:NO SIGNIFICANT CHANGE. SGPT:SLIGHTLY ELEVATED IN 4 CASES,BUT RECOVERY. LIBIDO AND POTENCY:SEEMINGLY DECREASED IN 1 CASE. HEMOGLOBIN,WBC AND DIFFERENTIAL,BLEEDING TIME,CLOTTING TIME,BLOOD PRESSURE AND TESTICULAR SIZE AND CONSISTENCY WERE OBSERVED IN PART OF THE CASES:NO SIGNIFICANT CHANGE. ONE CASE DEVELOPED ACUTE GASTROENTERITIS-LIKE SYMPTOMS AND SHORTLY RECOVERED AFTER SYMPTOMATIC TREATMENT.
Dose amount60-70 MG
Number3
Qualitative resultACTIVE
AnimalHUMAN ADULT
Per unitPERSON
Dose expressionDOSE
GenderMALE