Experiment 1272648
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Empty organism |
| Citation | QIAN,SZ: CHENG,DD: YE,GC: XU,Y: LI,YQ:. (1980). GOSSYPOL-INDUCED HYPERPROSTAGLADINURIA AND ITS CURE BY INDOMETHACIN. A PRELIMINARY REPORT.. () |
| Amount utilized | |
| Compound isolated | |
| Disease | OBSERVATION THAT LEVELS OF PROSTAGLANDIN-LIKE SUBSTANCES INCREASED IN THE URINE OF 14 HEALTHY MALES AND IN TWO CASES OF GOSSYPOL-RELATED KYPOKALEMIC PARALYSIS THROUGH BIOLOGICAL ASSAY. INDICATION THAT 24-HOUR URINARY PROSTAGLANDIN-LIKE SUBSTANCES OOF THE SUBJECTS WAS 3-6 FOLD MORE ABUNDANT THAN THAT OF HEALTHY MEN. IN ONE SUBJECT, RESISTANT HYPOKALEMIA, POLYURIA AND FATIGUABILITY PERSISTED EVEN WITH K THERAPY FOR ONE MONTH THE CONDITION IS DRAMATICALLY IMPROVED WITH NORMALIZATION OF URINARY PROSTAGLANDIN-LIKE SUBSTANCE LEVELS AFTER ADMINISTRATION OF INDOMETHACIN (75 MG/DAY P.O. FOR 10 DAYS) IN ADDITION TO ROUTINE K REPLETION. IT IS HYPOTHESIZED THAT INCREASED RENAL PROSTAGLANDIN BIOSYNTHESIS MAY PLAY A PART IN THE PATHOGENESIS OF GOSSYPOL-RELATED HYPOKALEMIC PARALYSIS. |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Dose expression | DOSE |
| Gender | MALE |