| Disease | GOSSYPOL TAKES FOR 3-5 MONTHS BRINGS ABOUT LOWERED SPERM COUNTS CONSIDERED NECESSARY FOR CONTRACEPTION. A SMALL MAINTENANCE DOSE IS USED TO MAINTAIN THESE LEVELS. TOXIC EFFECTS APPEAR MOST OFTEN IN THE EARLY DAYS OF DRUG ADMINISTRATION THEN DISAPPEAR
THESE INCLUDE (WITH PERCENTAGE OF PATIENT POPULATION OF 151 FROM A 1971 STUDY: WEAKNESS(14%),NAUSEA(5.29%),THIRST(1.32%),APPETITE INCREASE(2%),APPETITE DECREASE(1.32%),DISTENTION(2%),DIZZINESS(2%),AND PALPITATION(0.66%).
DISTURBANCE OF SEXUAL FUNCTION (DECREASE IN LIBIDO, IMPOTENCE) WAS SEEN IN 8 CASES(5.29%*. 4 CASES RECOVERED AFTER A SHORT PERIOD OF TIME, 2 CASES RECOVERED AFTER EXPLANATION, AND IN 2 CASES THE SYMPTOMS RECURRED.
A FEW PATIENTS SHOWED TRANSIENT ABNORMAL LIVER FUNCTION (SGPT INCREASE) AND HYPOKALEMIC MYASTHENIA.
MORPHOLOGICAL STUDIES OF SPERMATOZOA OF PATIENTS SHOWED AN INCREASE IN THE NUMBER OF ANOMALIES IN THE SPERM INCLUDING VACUOLIZATION OF THE MITOCHONDRIA WITH DISAPPEARANCE OF CRISTEA, AND DISTURBANCE OF OXIDATIVE METABOLISM. |