Experiment 1276771
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Cimicifuga racemosa (RANUNCULACEAE) |
| Citation | UEBELHACK,R: BLOHMER,JU: GRAUBAUN,HJ: BUSCH,R: GRUENWALD,J: WERNECKE,KD:. (2006). BLACK COHOSH AND ST. JOHN'S WORT FOR CLIMACTERIC COMPLAINTS A RANDOMIZED TRIAL.. 107(2) |
| Amount utilized | |
| Compound isolated | |
| Disease | DOUBLE-BLIND RANDOMIZED PLACEBO-CONTROL STUDY, 301 WOMEN EXPERIENCING CLIMACTERIC COMPLAINTS WITH PSYCHOLOGICAL SYMPTOMS WERE TREATED WITH ETHANOLIC ST. JOHN’S WORT EXTRACT AND ISOPROPANOLIC BLACK COHOSH EXTRACT OR A MATCHED PLACEBO FOR 16 WEEKS. CLIMACTERIC COMPLAINTS WERE EVALUATED USINGTHE MENOPAUSE RATING SCALE MEAN SCORE, AND PSYCHOLOGICAL COMPLAINTS WERE EVALUATED USING THE HAMILTON DEPRESSION RATING SCALE SUM SCORE. MEAN MENOPAUSE RATING SCALE SCORE DECREASED 50% IN THE TREATMENT GROUP AND 19.6% IN THE PLACEBO GROUP. DEPRESSION RATING SCALE SCORE DECREASED 41.8% IN THE TREATMENT GROUP AND 12.7% IN THE PLACEBO GROUP TREATMENT WAS SIGNIFICANTLY SUPERIOR TO PLACEBO IN BOTH MEASURES. A COMMERCIAL PRODUCT, REMIFEMIN, WAS USED. |
| Dose amount | 40.0 MG |
| Number | 3 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | DAY |
| Dose expression | DOSE |
| Extract | ISOPROPANOL(40%) EXT |
| Gender | FEMALE |