Experiment 1289176
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Boswellia serrata (BURSERACEAE) |
| Citation | SONTAKKE,S: THAWANI,V: PIMPALKHUTE,S: KABRA,P: BABHULKER,S: HINGORANI,L:. (2007). OPEN RANDOMIZED CONTROLLED CLINICAL TRIAL OF BOSWELLIA SERRATA EXTRACT AS COMPARED TO VALDECOXIB IN OSTEOARTHRITIS OF THE KNEE. 39(1) |
| Amount utilized | |
| Compound isolated | |
| Disease | STUDY COMPARING THE EFFICACY, SAFETY AND TOLERABILITY OF BOSWELLIA SERRATA EXTRACT (BSE) IN OSTEOARTHRITIS (OA) KNEE WITH VALDECOXIB, A SELECTIVE COX-2 INHIBITOR. MATERIALS AND METHODS: IN A RANDOMIZED, PROSPECTIVE, OPEN-LABEL, COMPARATIVE STUDY THE EFFICACY, SAFETY AND TOLERABILITY OF BSE WAS COMPARED WITH VALDECOXIB IN 66 PATIENTS OF OA OF KNEE FOR SIX MONTHS. THE PATIENTS WERE ASSESSED BY WOMAC SCALE AT BASELINE AND THEREAFTER AT MONTHLY INTERVAL TILL 1 MONTH AFTER DRUG DISCONTINUATION. ANTERO-POSTERIOR RADIOGRAPHS OF AFFECTED KNEE JOINT WERE TAKEN AT BASELINE AND AFTER 6 MONTHS. RESULTS: IN BSE GROUP THE PAIN, STIFFNESS, DIFFICULTY IN PERFORMING DAILY ACTIVITIES SHOWED STATISTICALLY SIGNIFICANT IMPROVEMENT WITH TWO MONTHS OF THERAPY WHICH EVEN LASTED TILL ONE MONTH AFTER STOPPING THE INTERVENTION. IN VALDECOXIB GROUP THE STATISTICALLY SIGNIFICANT IMPROVEMENT IN ALL PARAMETERS WAS REPORTED AFTER ONE MONTH OF THERAPY BUT THE EFFECT PERSISTED ONLY AS LONG AS DRUG THERAPY CONTINUED. THREE PATIENTS FROM BSE GROUP AND TWO FROM VALDECOXIB GROUP COMPLAINED OF ACIDITY. ONE PATIENT FROM BSE GROUP COMPLAINED OF DIARRHEA AND ABDOMINAL CRAMPS. CONCLUSION: BSE SHOWED A SLOWER ONSET OF ACTION BUT THE EFFECT PERSISTED EVEN AFTER STOPPING THERAPY WHILE THE ACTION OF VALDECOXIB BECAME EVIDENT FASTER BUT WANED RAPIDLY AFTER STOPPING THE TREATMENT. |
| Dose amount | 1.0 GM |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | DAY |
| Dose expression | DOSE |
| Extract | GUM RESIN |