Experiment 1317306
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Justicia adhadota (ACANTHACEAE) |
| Citation | BARTH,A: HOVHANNISYAN,A: JAMALYAN,K: NARIMANYAN,M:. (2015). ANTITUSSIVE EFFECT OF A FIXED COMBINATION OF JUSTICIA ADHATODA, ECHINACEA PURPUREA AND ELEUTHEROCOCCUS SENTICOSUS EXTRACTS IN PATIENTS WITH ACUTE UPPER RESPIRATORY TRACT INFECTION: A COMPARATIVE, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY. 22(13) |
| Amount utilized | |
| Compound isolated | |
| Disease | CLINICAL EVALUATION OF THE ANTITUSSIVE EFFECT OF KANJ JANG (KJ) ORAL SOLUTION AMONG PATIENTS OF 18–65 YEARS OLD WITH NON-COMPLICATED UPPER RESPIRATORY INFECTIONS (URI) BY A PARALLEL-GROUP, RANDOMIZED, DOUBLE-BLINDED, PLACEBO-CONTROLLED TRIAL IN 177 PATIENTS WITH ACUTE URI OVER A 5 DAY PERIOD. ANTITUSSIVE EFFECTS OF A KJ (30 ML/DAY; 762 MG GENUINE EXTRACTS WITH STANDARDIZED CONTENTS OF 0.2 MG/ML VASICINE, 0.8 MG/ML CHICORIC ACID, AND 0.03 MG/ML ELEUTHEROSIDES B AND E),OR BROMHEXINE HYDROCHLORIDE (BH-24 MG/30 ML/DAY) AND PLACEBO ON COUGH AND BLOOD MARKERS. THE PRIMARY OUTCOME WAS COUGH RELIEF, WHICH WAS ASSESSED AS THE CHANGE OF COUGH FREQUENCY FROM BASELINE (COUGH INDEX). SECONDARY OUTCOMES WERE SAFETY WITH REGARDS TO REPORTED ADVERSE EVENTS (AES) AND HEMATOLOGICAL DATA.BOTH KJ AND BH RELIEVED COUGH MORE EFFECTIVELY THAN PLACEBO. ON THE THIRD AND FOURTH DAYS OF TREATMENT, FASTER IMPROVEMENT IN THE GROUP RECEIVING KJ INDICATED A SLIGHTLY SHORTER RECOVERY TIME IN THE KJ GROUP. KJ SHOWED A GOOD TOLERABILITY AND SAFETY PROFILE. CONCLUSION: KJ EXERTED SIGNIFICANT ANTITUSSIVE EFFECTS IN URI. THE PRESENT DATA FURTHER SUPPORT THE THERAPEUTIC USE OF KJ IN UPPER RESPIRATORY TRACT INFECTION. |
| Dose amount | 30 ML |
| Number | 10 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | DAY |
| Dose expression | DOSE |
| Extract | ETOH(95%)EXT |
| Gender | GIVEN TO BOTH SEXES |