Experiment 1324142

Worktypes

MECHANISM OF ACTION STUDIEDEFFECTS DUE TO A COMBINATION OF DRUGSPHARMACOLOGY OF EXTRACT - IN VIVO

Alerts

VS. NITROGLYCERINE-INDUCED MIGRAINEEFFECTS DESCRIBED ARE FROM A MULTI-COMPONENT RX.

Details

PropertyValue
Pharmacology
ANALGESIC ACTIVITY
Administration routeINTRAGASTRIC
OrganismCyperus rotundus (CYPERACEAE)
CitationGUO.L: GONG,MX: WU,S: QIU,F: MA,L:. (2020). IDENTIFICATION AND QUANTIFICATION OF THE QUALITY MARKERS AND ANTI-MIGRAINE ACTIVE COMPONENTS IN CHUANXIONG RHIZOMA AND CYPERI RHIZOMA HERBAL PAIR BASED ON CHEMOMETRIC ANALYSIS BETWEEN CHEMICAL CONSTITUENTS AND PHARMACOLOGICAL EFFECTS. 246(1122228)
Amount utilized
Compound isolated
DiseaseA MIXTURE OF LIGUSTICUM CHUANXIONG AND CYPERUS ROTUNDUS RHIZOMES WAS EVALUATED. BIOACTIVITY PROFILES WERE INFERRED BY LEVELS OF MIGRAINE-RELATED NEUROTRANSMITTERS AND NEUROPEPTIDES (5-HYDROXYTRYPTAMINE (5-HT), CALCITONIN GENE-RELATED PEPTIDE (CGRP), Β-ENDORPHIN (Β-EP), VASOACTIVE INTESTINAL PEPTIDE (VIP) AND NITRIC OXIDE SYNTHASE (NOS)) IN BRAINSTEM.
Dose amount6 GM
Number3
AnimalRAT
Per unitKG
Dose expressionDOSE
ExtractETOH(70%)EXT