Experiment 1324153

Details

PropertyValue
Pharmacology
OrganismAesculus hippocastanum (HIPPOCASTANACEAE)
CitationISOLA,G: MATARESE,M: RAMAGLIA,L: IORIO-SICILIANO,V: CORDASCO,G: GIOVANNI MATARESE,G:. (2019). EFFICACY OF A DRUG COMPOSED OF HERBAL EXTRACTS ON POSTOPERATIVE DISCOMFORT AFTER SURGICAL REMOVAL OF IMPACTED MANDIBULAR THIRD MOLAR: A RANDOMIZED, TRIPLE-BLIND, CONTROLLED CLINICAL TRIAL. 22()
Amount utilized
Compound isolated
DiseaseEIGHTY-TWO PATIENTS REQUIRING SURGICAL REMOVAL OF A MANDIBULAR THIRD MOLAR WERE RANDOMLY ASSIGNED TO RECEIVE PLACEBO (GROUP 1), IBUPROFEN (GROUP 2), AND A PHYTOTHERAPEUTIC DRUG (COMPOSED OF BAICALIN, 190 MG; BROMELAIN, 50 MG; AESCIN, 30 MG) (GROUP 3). DRUGS WERE ADMINISTERED AFTER TOOTH EXTRACTION TWICE A DAY FOR 5 DAYS. THE PRIMARY OUTCOME, PAIN, WAS EVALUATED USING A VISUAL ANALOGUE SCALE. SECONDARY OUTCOMES WERE CHANGES IN MAXIMUM MOUTH OPENING AND FACIAL CONTOURS (MM) BETWEEN BASELINE AND AT 24 H, 72 H, AND 7 AND 10 DAYS AFTER SURGERY. COMPARED TO THE BASELINE, ALL TREATMENTS DEMONSTRATED AN IMPROVEMENT IN THE PRIMARY AND SECONDARY OUTCOMES. MOREOVER, COMPARED TO GROUPS 1 AND 2, PATIENTS IN GROUP 3 YIELDED A SIGNIFICANT REDUCTION OF THE POSTOPERATIVE PAIN SCORE AT 12 H (P < 0.001), 24 H (P = 0.010), AND 48 H (P = 0.048) AFTER SURGERY. THE MEAN REDUCTION OF THE SWELLING AND TRISMUS WAS SIMILAR BETWEEN GROUPS.THE RESULTS OF THIS STUDY SUGGEST THAT A POSTOPERATIVE ADMINISTRATION OF A PHYTOTHERAPEUTIC DRUG WAS FOUND TO BE EFFECTIVE IN POSTOPERATIVE PAIN MANAGEMENT AFTER THE SURGICAL REMOVAL OF IMPACTED MANDIBULAR THIRD MOLARS.
Dose amount60
Number1
Qualitative resultACTIVE
AnimalHUMAN ADULT
Per unitDAY
Dose expressionDOSE