Experiment 1324164
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | INTRA-ARTICULAR |
| Organism | Clostridium botulinum (CLOSTRIDIACEAE) |
| Citation | MAHOWALD,ML: KRUG,HE: SINGH,JA: DYKSTRA,D:. (2009). INTRA-ARTICULAR BOTULINUM TOXIN TYPE A: A NEW APPROACH TO TREAT ARTHRITIS JOINT PAIN. 54() |
| Amount utilized | |
| Compound isolated | |
| Disease | DATA FROM SEVERAL SMALL OPEN LABEL STUDIES, WHOSE INITIAL EFFECTS SHOWED TWO THIRDS OF THE PATIENTS HAD MORE THAN 50% REDUCTION IN JOINT PAIN SEVERITY THAT WAS ASSOCIATED WITH A SIGNIFICANT IMPROVEMENT IN FUNCTION. IMPORTANTLY NO SERIOUS ADVERSE EFFECTS WERE NOTED. BASED ON THESE INITIAL RESULTS, TWO PILOT RANDOMIZED CONTROLLED TRIALS IN PAINFUL SHOULDER JOINTS AND PAINFUL KNEE JOINTS WERE CONDUCTED. IN THE SHOULDER STUDY, A SIGNIFICANT DECREASE IN SHOULDER PAIN SEVERITY AT ONE MONTH WAS NOTED. IN THE KNEE STUDY A SIGNIFICANT 48% DECREASE IN MCGILL TOTAL PAIN SCORE AT ONE MONTH WAS STILL SIGNIFICANT AT 3 MO AFTER INJECTION. |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Dose expression | DOSE VARIABLE |