Experiment 1324236
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Curcuma longa (ZINGIBERACEAE) |
| Citation | MADHU,K: CHANDA,K: SAJI,MJ:. (2013). SAFETY AND EFFICACY OF CURCUMA LONGA EXTRACT IN THE TREATMENT OF PAINFUL KNEE OSTEOARTHRITIS: A RANDOMIZED PLACEBO-CONTROLLED TRIAL. 21() |
| Amount utilized | |
| Compound isolated | |
| Disease | RANDOMIZED, SINGLE BLIND, PLACEBO-CONTROLLED TRIAL. TOTAL OF 120 PATIENTS (37 MALES AND 83 FEMALES) WITH PRIMARY KNEE OSTEOARTHRITIS RECEIVED EITHER PLACEBO OR CURCUMA LONGA RHIZOME EXTRACT (500 MG TWICE DAILY) OR GLUCOSAMINE SULPHATE (750 MG TWICE DAILY) ALONE OR IN COMBINATION WITH CURCUMA EXTRACT FOR 42 DAYS. THE EFFICACY WAS ASSESSED DURING ON DAY 21 AND DAY 42. PRIMARY OUTCOMES -DECREASE IN SEVERITY OF PAIN SYMPTOM AND FUNCTION OF AFFECTED KNEE AS ASSESSED BY VISUAL ANALOG SCALE (VAS) AND WESTERN ONTARIO AND MCMASTER UNIVERSITIES OSTEOARTHRITIS INDEX (WOMAC) SCALE, RESPECTIVELY. THE CLINICAL EXAMINATION OF AFFECTED JOINT WAS MEASURED BY AN ORTHOPAEDIC SPECIALIST AND USING A CLINICIAN GLOBAL IMPRESSION CHANGE (CGIC) SCALE. CURCUMA GROUP GROUP SHOWED A SIGNIFICANT (DECREASE IN USE OF RESCUE MEDICATION, ALONG WITH CLINICAL AND SUBJECTIVE IMPROVEMENT COMPARED TO PLACEBO. |
| Dose amount | 1000 MG |
| Number | 0 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | DAY |
| Dose expression | DOSE |
| Extract | TYPE EXT NOT STATED |