Experiment 1324255

Worktypes

CLINICAL STUDIES

Details

PropertyValue
Pharmacology
ANALGESIC ACTIVITY
Administration routeORAL
OrganismMomordica charantia (CUCURBITACEAE)
CitationMAY,LS: SANIP,Z: SHOKRI,AA: KADIR,AA: RIZMAN,M: LAZIN,M:. (2018). THE EFFECTS OF MOMORDICA CHARANTIA (BITTER MELON) SUPPLEMENTATION IN PATIENTS WITH PRIMARY KNEE OSTEOARTHRITIS: A SINGLE-BLINDED, RANDOMIZED CONTROLLED TRIAL. 32()
Amount utilized
Compound isolated
DiseaseSINGLE-BLINDED, PLACEBO-CONTROLLED RANDOMIZED CONTROLLED STUDY. THIRTY-EIGHT AND THIRTY-SEVEN PRIMARY KNEE OSTEOARTHRITIS PATIENTS UNDERWENT 3 MONTHS OF MOMORDICA CHARANTIA AND PLACEBO SUPPLEMENTATION RESPECTIVELY. THREE 500 MG PER CAPSULE OF MOMORDICA CHARANTIA WERE TAKEN THRICE DAILY. RESCUE ANALGESIA WAS ALLOWED AS NEEDED. PAIN AND SYMPTOMS THROUGHOUT THE MOMORDICA CHARANTIA SUPPLEMENTATION PERIOD WERE ASSESSED USING KNEE INJURY AND OSTEOARTHRITIS OUTCOME SCORE AND EQ-5D-3L HEALTH QUESTIONNAIRE, WHILE RESCUE ANALGESIA INTAKE THROUGHOUT THE PERIOD OF SUPPLEMENTATION WAS MEASURED USING ANALGESIC SCORE. RESULTS: AFTER 3 MONTHS SUPPLEMENTATION PERIOD, BODY WEIGHT, BODY MASS INDEX, AND FASTING BLOOD GLUCOSE REDUCED SIGNIFICANTLY IN THE MOMORDICA CHARANTIA GROUP. THERE WERE ALSO SIGNIFICANT IMPROVEMENTS IN KNEE INJURY AND OSTEOARTHRITIS OUTCOME SCORE SUBSCALES AND EQ-5D-3L DIMENSION SCORE, AND REDUCTION IN ANALGESIC SCORE. THE PLACEBO GROUP HAD ALSO SHOWN SIGNIFICANT IMPROVEMENTS IN CERTAIN KNEE INJURY AND OSTEOARTHRITIS OUTCOME SCORE SUBSCALES AND EQ-5D-3L DIMENSION SCORE, BUT WITH INCREASED OF THE ANALGESIC SCORE. CONCLUSION: MOMORDICA CHARANTIA SUPPLEMENTATION OFFERS A SAFE ALTERNATIVE TO REDUCING PAIN AND IMPROVING SYMPTOMS AMONG THE PRIMARY KNEE OSTEOARTHRITIS PATIENTS WHILE REDUCING THE NEED FOR ANALGESIA CONSUMPTION. THESE BENEFICIAL EFFECTS CAN BE SEEN AS EARLY AS 3 MONTHS OF SUPPLEMENTATION.
Dose amount1500 MG
Number0
Qualitative resultACTIVE
AnimalHUMAN ADULT
Per unitDAY
Dose expressionDOSE
ExtractTYPE EXT NOT STATED