Experiment 1324710
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | (PINACEAE) |
| Citation | BELCARO,G: CESARONE,MR: ERRICHI,S: ZULLI,C: ERRICHI,BM: VINCIGUERRA,G: LEDDA,A: DI RENZO,A: STUARD,S: DUGALL,M: PELLEGRINI,L: GIZZI,G: IPPOLITO,E: RICCI,A: CACCHIO,M: CIPOLLONE,G: RUFFINI,I: FANO,F: HOSOI,M: ROHDEWALD,P:. (2008). VARIATIONS IN C-REACTIVE PROTEIN, PLASMA FREE RADICALS AND FIBRINOGEN VALUES IN PATIENTS WITH OSTEOARTHRITIS TREATED WITH PYCNOGENOL. 13(6) |
| Amount utilized | |
| Compound isolated | |
| Disease | CLINICAL INVESTIGATION OF THE ANTIINFLAMMATORYAND ANTIOXIDANT ACTIVITY OF PYCNOGENOL® IN A SUBSET OF THE OSTEOARTHRITIS PATIENTS PRESENTING WITH ELEVATED C-REACTIVE PROTEIN (CRP) AND PLASMA-FREE RADICALS. ELEVATED CRP LEVELS HAVE BEEN SUGGESTED TO BE ASSOCIATED WITH DISEASE PROGRESSION IN OSTEOARTHRITIS. IN OUR STUDY, 29 SUBJECTS OF THE PYCNOGENOL® GROUP AND 26 PATIENTS IN THE PLACEBO GROUP SHOWED CRP LEVELS HIGHER THAN 3 MG/L AT BASELINE. COMPARISON OF BLOOD SPECIMENS DRAWN AT BASELINE AND AFTER 3-MONTH TREATMENT SHOWED THAT PYCNOGENOL® SIGNIFICANTLY DECREASED PLASMA FREE RADICALS TO 70.1% OF BASELINE VALUES. PLASMA CRP LEVELS DECREASED FROM BASELINE 3.9 MG/L TO 1.1 MG/L IN THE PYCNOGENOL® GROUP WHEREAS THE CONTROL GROUP HAD INITIAL VALUES OF 3.9 MG/L WHICH DECREASED TO 3.6 MG/L. THE CRP DECREASE IN THE PYCNOGENOL® WAS STATISTICAL SIGNIFICANT AS COMPARED TO THE CONTROL GROUP (P < 0.05). FIBRINOGEN LEVELS WERE FOUND TO BE LOWERED TO 62.8% OF INITIAL VALUES (P < 0.05) IN RESPONSE TO PYCNOGENOL®. NO SIGNIFICANT CHANGES FOR PLASMA FREE RADICALS, CRP AND FIBRINOGEN WERE FOUND IN THE PLACEBO-TREATED GROUP. THE DECREASE OF SYSTEMIC INFLAMMATORY MARKERS SUGGESTS THAT PYCNOGENOL® MAY EXERT ANTI-INFLAMMATORY ACTIVITY IN OSTEOARTHRITIC JOINTS AND PATIENTS DID NOT PRESENT WITH OTHER AILMENTS OR INFECTIONS. THE NATURE OF THE ANTI-INFLAMMATORY EFFECTS OF PYCNOGENOL® WITH REGARD TO CRP WARRANTS FURTHER INVESTIGATION. |
| Dose amount | 100 MG |
| Number | 3 |
| Quantitative result | + |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | DAY |
| Dose expression | DOSE |
| Gender | GIVEN TO BOTH SEXES |