Experiment 152541

Details

PropertyValue
Pharmacology
OrganismLeucetta microraphis (LEUCETTIDAE)
CitationCHAN,GW: MONG,S: HEMLING,ME: FREYER,AJ: OFFEN,PH: DE BROSSE,CW: SARAU,HM: WESTLEY,JW:. (1993). NEW LEUKOTRIENE B4 RECEPTOR ANTAGONIST: LEUCETTAMINE A AND RELATED IMIDAZOLE ALKALOIDS FROM THE MARINE SPONGE LEUCETTA MICRORAPHIS.. 56(1)
Amount utilized
Compound isolated
DiseaseU937 CELLS WERE FURA-2 LOADED. IT DID NOT REDUCE A CA+2 TRANSIENT ON ITS OWN BUT WAS ABLE TO BLOCK THE LTB4-INDUCED CA+2 TRANSIENT. THIS RESULT SUGGESTS THAT THE COMPOUND IS A PURE ANTAGONIST OF THE LTB4 RECEPTOR.
Dose amount4.6 MILLIMOLS
Number6
Qualitative resultINACTIVE
Dose expressionIC50