Experiment 170384

Worktypes

PHARMACOLOGY OF COMPOUND - IN VITRO

Compounds isolated

MERIDAMYCIN

Details

PropertyValue
Pharmacology
FKBP12(FK506 BINDING PROTEIN) BINDING ACTIVITY
OrganismStreptomyces hygroscopicus (STREPTOMYCETACEAE)
CitationSALITURO,GM: ZINK,DL: DAHL,A: NIELSEN,J: WU,E: HUANG,LY: KASTNER,C: DUMONT,FJ:. (1995). MERIDAMYCIN: A NOVEL NONIMMUNOSUPPRESSIVE FKBP12 LIGAND FROM STREPTOMYCES HYGROSCOPICUS.. 36(7)
Amount utilized
Compound isolated
DiseaseCOMPOUND INHIBITS BINDING OF IMMUNOSUPPRESSANTS FK-506 OR PAPAMYCIN TO FKBP12 RECEPTOR BUT IS NOT IMMUNOSUPPRESSANT ITSELF.
Dose amount1.0 NG
Number2
Qualitative resultACTIVE
AnimalMOUSE
Per unitML
Dose expressionIC50