Experiment 182830

Worktypes

PHARMACOLOGY OF COMPOUND - IN VITRO

Compounds isolated

STREPTOMYCES ANTIBIOTIC U-106305

Details

PropertyValue
Pharmacology
CHOLESTEROL ESTER FORMATION INHIBITION
OrganismStreptomyces species (STREPTOMYCETACEAE)
CitationKUO,MS: ZIELINSKI,RJ: CIALDELLA,JI: MARSCHKE,CK: DUPUIS,MJ: LI,GP: KLOOSTERMAN,DA: SPILMAN,CH: MARSHALL,VP:. (1995). DISCOVERY, ISOLATION, STRUCTURE ELUCIDATION, AND BIOSYNTHESIS OF U-106305, A CHOLESTERYL ESTER TRANSFER PROTEIN INHIBITOR FROM UC 11136.. 117(43)
Amount utilized
Compound isolated
DiseaseCHOLESTEROL ESTER TRANSFERASE PROTEIN INHIBITION ASSAYED.
Dose amount25.0 MICROMOLS
Number2
Qualitative resultACTIVE
Dose expressionIC50