| Disease | MIROESTROL WAS ADMINISTERED TO TEN WOMEN SUFFERING FROM AMENORRHEA (PRIMARY, TWO CASES; SECONDARY, SEVEN EASES) OR ARTIFICIAL MENOPAUSE (ONE CASE). 5 MGM. DAILY WAS GIVEN ON SIX OCCASIONS AND 1 MGM. DAILY ON ANOTHER SIX OCCASIONS. MARKED ESTROGEN RESPONSE WAS NOTED WITH BOTH THESE DOSES ON THE VAGINAL SMEAR, THE MAXIMUM RISE IN THE CORNIFICATION INDEX USUALLY OCCURRING DURING THE SECOND OR THIRD WEEK AFTER TREATMENT COMMENCED. THIS PEAK USUALLY OCCURRED, THEREFORE, AFTER THE TREATMENT HAD BEEN DISCONTINUED.
ESTROGEN WITHDRAWAL BLEEDING FAILED TO TAKE PLACE ON SIX OCCASIONS (THREE WITH DOSES OF I MGM. DAILY FROM 5 TO 10 DAYS; THREE WITH DOSES OF 5 MGM. DAILY FROM 2 TO 14 DAYS), THOUGH WITHDRAWAL BLEEDINGS HAD USUALLY OCCURRED IN THESE PATIENTS WHEN THEY HAD BEEN PREVIOUSLY TREATED WITH ESTROGENS. WITHDRAWAL BLEEDING DID TAKE PLACE ON FIVE OCCASIONS, HOWEVER, 7-18 DAYS AFTER THE CESSATION OF TREATMENT.
NO TOXIC EFFECTS WERE COMPLAINED OF ON THREE OCCASIONS, THE DOSES BEING I MGM. DAILY FOR 7 DAYS, 5 MGM. DAILY FOR 8 DAYS AND 5 MGM. DAILY FOR 14 DAYS, RESPECTIVELY.
TOXIC EFFECTS WERE RATHER MARKED ON THE REMAINING NINE OCCASIONS AND CONSISTED OF MALAISE, HEADACHE, NAUSEA AND IN SOME INSTANCES VOMITING. THEY DID NOT SEEM TO BE APPRECIABLY LESS SEVERE ON THE 1-MGM. DOSES THAN ON THE 5-MGM. DOSES. ON FOUR OCCASIONS THERE WAS ENLARGEMENT AND TENDERNESS OF THE BREASTS. THESE CHANGES WERE MORE SEVERE AND MORE FREQUENT ON THE 5-MGM. DOSES. ON TWO OCCASIONS THEY WERE ACCOMPANIED BY MARKED PIGMENTATION OF THE NIPPLES, WHICH PERSISTED FOR SOME TIME. IN THE PATIENT WHO HAD RECEIVED AN ARTIFICIAL MENOPAUSE THE HOT FLUSHES DIMINISHED IN
FREQUENCY AND SEVERITY FOR THE FIRST WEEK OF THE 14-DAY COURSE, BUT BEGAN TO RETURN BY THE FIFTH DAY AFTER TREATMENT HAD BEEN DISCONTINUED. |