Experiment 237540

Worktypes

PHARMACOLOGY OF COMPOUND - IN VITRO

Compounds isolated

AZAPHILONE RP-1551-M-1

Details

PropertyValue
Pharmacology
PLATELET ACTIVATING FACTOR BINDING INHIBITION
OrganismPenicillium species (HYPHOMYCETES)
CitationTOKI,S: TANAKA,T: UOSAKI,Y: YOSHIDA,M: SUZUKI,Y: KITA,K: MIHARA,A: ANDO,K: LOKKER,NA: GIESE,NA: MATSUDA,Y:. (1999). RP-1551S, A FAMILY OF AZAPHILONES PRODUCED BY PENICILLIUM SP.. INHIBIT THE BINDING OF PDGF TO THE EXTRACELLULAR DOMAIN OF ITS RECEPTOR.. 52(3)
Amount utilized
Compound isolated
DiseaseVS.PDGF AA TO THE ALPHA-RECEPTOR.
Dose amount0.42 MICROMOLS
Number25
Qualitative resultSTRONG ACTIVITY
Dose expressionIC50