Experiment 321722
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | IV INFUSION |
| Organism | Empty organism |
| Citation | SAMUELS,ML: JOHNSON,DE: HOLOYE,PY:. (1975). CONTINUOUS INTRAVENOUS BLEOMYCIN (NSC-125066) THERAPY WITH VINBLASTINE (NSC-49842) IN STAGE III TESTICULAR NEOPLASIA.. 59() |
| Amount utilized | |
| Compound isolated | |
| Disease | 23 PATIENTS WITH STAGE 3 GERMINAL NEOPLASIA OF THE TESTIS WERE USED IN THIS STUDY. PATIENTS WERE GIVEN 0.4 MG/KG VBL IN 2 FRACTIONS ON DAYS 1 AND 2 FOLLOWED BY CONTINUOUS IV ADMINISTRATION OF 30 UNITS OF BLEOMYCIN OVER A 24 HR PERIOD FOR 5 DAYS. THERAPY WAS REPEATED EVERY 28-35 DAYS. THERE WERE 17 PATIENTS WITH TUMOR REGRESSION, 9 OF WHICH WERE COMPLETE. TOXICITIES INCLUDED LEUKOPENIA, THROMBOPENIA AND TRANSIENT HYPERBILIRUBINEMIA IN 90%, 50% AND 30% OF THE PATIENTS RESPECTIVELY. 4 PATIENTS EXPERIENCED HYPERTENSION. BLEOMYCIN PNEUMOCYSTIS OCCURRED IN 1 PATIENT AND RESULTED IN DEATH. |
| Dose amount | 30.0 UNITS |
| Number | 1 |
| Qualitative result | . |
| Animal | HUMAN ADULT |
| Dose expression | DOSE |