Experiment 347445

Details

PropertyValue
Pharmacology
Administration routeINTRAGASTRIC
OrganismEmpty organism
CitationWANG,PQ: CHEN,SX: ZHU,XB: LI,D: LU,GH: CHEN,MF:. (1996). PHARMACOKINETICS OF MATRINE IN RATS.. 16(4)
Amount utilized
Compound isolated
DiseaseTHE CONCN.-TIME CURVE OF MATRINE IN BLOOD CONFORMED TO AN OPEN 2-COMPARTMENT MODEL AFTER 50 MG/KG INTRAGASTRIC. MATRINE ABSORPTION WAS RAPID AND COMPLETE. THE PEAK PLASMA AND TISSUE LEVELS APPEARED IN 0.5 H. THE DISTRIBUTION OF MATRINE IN RAT TISSUES WERE AS FOLLOWS: HIGHEST IN KIDNEY, NEXT IN LIVER, SPLEEN, LUNG, HEART, BRAIN, AND BLOOD, RESP.; THE LEVELS WERE STILL DETECTED AFTER 48H. URINE WAS THE MAIN ROUTE OF EXCRETION. THERE WAS NO ACCUMULATION INRATS AFTER 50 MG/KG INTRAGASTRIC 21 DAYS.
Dose amount50.0 MG
Number1
Qualitative resultACTIVE
AnimalRAT
Per unitKG
Dose expressionDOSE