Experiment 347602
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | IP |
| Organism | Empty organism |
| Citation | LIU,L: BUCHNER,E: BEITZE,D: SCHMIDT-WEBER,CB: KAEVER,V: EMMRICH,F: KINNE,RW:. (1996). AMELIORATION OF RAT EXPERIMENTAL ARTHRITIDES BY TREATMENT WITH THE ALKALOID SINOMENINE.. 18(10) |
| Amount utilized | |
| Compound isolated | |
| Disease | MAXIMAL PLASMA CONCENTRATION OF SINOMENINE (22.5 MICROL G/ML; 68.3 MIRCOL M) WERE REACHED WITHIN 30 MIN FOLLOWING BOTH FIRST OR SECOND I.P. INJECTION OF 150 MG/KG INTO NORMAL FEMALE LEWIS RATS. HALF-MAXIMAL PLASMA CONCENTRATIONS WERE REACHED WITHIN 2 H FOLLOWING INJECTION. THE FINAL PLASMA HALF-LIE OF THE DRUG WAS CALCULATED AS 4.24+0.99 H (MEAN+S.E.M; N=17). FOLLOWING BOTH FIRST AND SECOND INJECTION, PLASMA LEVELS OF SINOMENINE REACHED LESS THAN 2 MICROL U/ML WITHIN 12 H, AND WERE BELOW THE DETECTION LIMIT AT 24 H; THERE WAS, THEREFORE, NO INDICATION FOR ACCUMULATION OF THE DRUG. |
| Dose amount | 150.0 MG |
| Number | 5 |
| Qualitative result | ACTIVE |
| Animal | RAT |
| Per unit | KG |
| Dose expression | DOSE |
| Gender | FEMALE |