Experiment 347702
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Urtica dioica (URTICACEAE) |
| Citation | TEUCHER,T: OBERTREIS,B: RUTTKOSKI,T: SCHMITZ,H:. (1996). CYTOKINE SECRETION IN WHOLE BLOOD OF HEALTHY VOLUNTEERS AFTER ORAL INGESTION OF AN URTICA DIOICA LEAF EXTRACT.. 46(9) |
| Amount utilized | |
| Compound isolated | |
| Disease | TWENTY HEALTHY VOLUNTEERS INGESTED FOR 21 DAYS 2 CAPSULES B.I.D. OF AN IDS 23/1 CONTAINING NETTLE LEAF EXTRACT. BEFORE AND AFTER 7 AND 21 DAYS, THE BASAL AND THE LIPOPOLYSACCHARIDE (LPS) STIMULATED TUMOR NECROSIS FACTOR-ALPHA (TNF-ALPHA), INTERLEUKIN-1-BETA (IL-1-BETA) AND INTERLEUKIN-6 (IL-6) CONCENTRATIONS WERE MEASURED EX VIVO. ORAL ADMINISTRATION OF THE TEST DRUG EX VIVO HAD NO EFECT ON BASAL LEVELS OF TNF-ALPHA, IL-1-BETA, IL-4, IL-6 OR IL-10 WHICH WERE ALWAYS BELOW DECTECTION LIMITS. AFTER 7 OR 21 DAYS INGESTION EX VIVO, A DECREASE OF LPS STIMULATED TNF-ALPHA RELEASE OF 14.6 AND 24.0%, RESPECTIVELY, WAS OBSERVED. IL-1-BETA WAS REDUCED FOR 19.2 AND 39.3%. |
| Dose amount | 670.0 MG |
| Number | 1 |
| Qualitative result | INACTIVE |
| Animal | HUMAN ADULT |
| Per unit | DAY |
| Dose expression | DOSE |
| Extract | TYPE EXT NOT STATED |
| Gender | GIVEN TO BOTH SEXES |