Experiment 347703

Details

PropertyValue
Pharmacology
OrganismUrtica dioica (URTICACEAE)
CitationTEUCHER,T: OBERTREIS,B: RUTTKOSKI,T: SCHMITZ,H:. (1996). CYTOKINE SECRETION IN WHOLE BLOOD OF HEALTHY VOLUNTEERS AFTER ORAL INGESTION OF AN URTICA DIOICA LEAF EXTRACT.. 46(9)
Amount utilized
Compound isolated
DiseaseIN VITRO IDS 23/1 ADDED TO WHOLE BLOOD RESULTED IN AN INHIBITON OF LPS STIMULATED TNF-ALPHA AND IL-1-BETA SECRETION. USING THE HIGHTEST TEST IDS-23/1 CONCENTRATION, THE INHIBITION REACHED 50.5% (DAY 0) TO 79.5% (DAY 21) FOR TNF-ALPHA AND 90.0% (DAY O) TO 99.2% (DAY 21) FOR IL, RESPECTIVELY. IDS 23/1 INDUCED A PRONOUNCED RELEASE OF IL-6 IN THE ABSENCE OF LPS ONLY IN VITRO. THE DETECTED IL-6 CONCENTRATIONS WERE COMPARABLE TO THOSE AFTER LPS STIMULATION. ADDITIVE EFFECTS COULD NOT BE OBSERVED.
Number2
Qualitative resultACTIVE
AnimalHUMAN ADULT
Dose expressionCONC USED
ExtractTYPE EXT NOT STATED