Experiment 351018
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | IV |
| Organism | Empty organism |
| Citation | TAKEDA,S: ISONO,T: WAKUL,Y: MIZUHARA,Y: AMAGAYA,S: MARUNO,M: HATTORI,M:. (1997). IN-VIVO ASSESSMENT OF EXTRAHEPATIC METABOLISM OF PAEONIFLORIN IN RATS: RELEVANCE TO INTESTINAL FLORAL METABOLISM.. 49(1) |
| Amount utilized | |
| Compound isolated | |
| Disease | PULMONARY EXTRACTION RATIO OF PAEONIFLORIN WAS ASSESSED BY COMPARING AUCS CALCULATED FROM VENOUS AND ARTERIAL PLASMA CONCENTRATIONS AFTER ITS INTRACENOUS ADMINISTRATION. THE MEAN PULMONARY EXTRACTION RATIO WAS ESTIMATED TO BE 0.06. THE PALSMA CONCENTRATION PROFILES OF PAEONIFLORIN AFTER INTRAPORTAL ADMINISTRATION WERE VERY CLOSE TO THOSE AFTER INTRAVENOUS ADMINISTRATION, SUGGESTING A NEGLIGIBLE HEPATIC EXTRACTION RATIO OF PAEONIFLORN. THE AUC VALUE AFTER INTRAPERITONEAL ADMINISTRATION (0.5 MG KG-1) WAS GREATER THAN THAT AFTER INTRAPORTAL OR INTRAVENOUS ADMINISTRATION. THIS FINDING SUGGESTS THAT PAEONIFLORIN IS NOT METABOLIZED IN THE GUT WALL. THE TRANSFERENCE OF PAEONIFLORIN FROM THE SEROSAL SIDE TO THE MUCOSAL SIDE WAS EVALUATED BY THE IN-VITO EVERTED SAC METHOD. THE LOW INTESTINAL PERMEABILITY (19.4% AT 60 MIN) WAS DEMOSTRATED BY THE COMPARISON WITH PHENOBARBITAL (63.1% AT 60 MIN). PAEONFIFLORIN IS NOT METABOLIZED BY GUT WALL, LIVER AND LUNG, ITS POOR ABSORPTION FROM THE INTESTINE RESULTS IN EXTREMELY LOW BIOAVAILABILITY AND THE UNABSORBED FRACTION OF PAEONFIFLORIN IS DEGRADED BY THE INTESTINAL FLORA. |
| Dose amount | 0.5 MG |
| Number | 1 |
| Qualitative result | . |
| Animal | RABBIT |
| Per unit | KG |
| Dose expression | DOSE |
| Gender | MALE |