Experiment 351341
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Empty organism |
| Citation | ASTRUP,A: BREUM,L: TOUBRO,S:. (1995). PHARMACOLOGICAL AND CLINICAL STUDIES OF EPHEDRINE AND OTHER THERMOGENIC AGONISTS.. 3(SUPP4) |
| Amount utilized | |
| Compound isolated | |
| Disease | WHEN GIVEN AS A SUPPLEMENT TO AN ENERGY RESTRICTED DIET THE SYMPATHOMIMETIC AGENT EPHEDRINE, IN COMBINATION WITH METHYLXANTHINES SUCH AS CAFFEINE, IMPROVES FAT LOOS BY DUAL ACTIONS: A CERTRAL SUPPRESSION OF APPETITE AND PERIPHERAL STIMULATION OF ENERGY EXPEDITURE COVERED BY FAT OXIDN. MENA WT. LOSS WAS FOUND TO BE 16.6 KG AFTER 6 MO WHEN E+C WAS GIVEN AS AN ADJUVANT TO AN EFFICIENT HYPOENERGETIC DIET, WHICH WAS 3.4 KG HIGHER THAN IN THE PLAEBO GROUP. AN ADDN. 24 WK TREATMENT WITH E+C PREVENTED RELAPSE. IN THE FIRST WEEKS OF TREATMENT E+C OFFSET THE HYPOTENSIVE EFFECT OF ENERGY RESTRICTION ANS WT. LOSS, BUT THE EFFECT WAS TRANSIENT, AND AFTER 8 WK BLOOD PRESSURES WERE INDISTINGUISHABLE FROM THOSE OF THE PLACEBO GROUP. E+C HAS NO ADVERSE EFFECT ON GLUCOSE AND LIPID METAB., BUT HAS BEEN SHOWN TO PREVENT THE DECLINE IN HDL-CHOLESTEROL CAUSED BY WT. LOSS. IN A COMPARATIVE TRIAL THE WT. LOSS PROEUCED BY E+C WAS SIMILAR TO THAT OF DEXFENFLURAMINE. MORE RESEARCH ON SYMPATHOMIMETICS AND METHYLXANTHINE SHOULD BE CARRED OUT OT IDENTIFY COMBINATIONS WITH IMPROVED EFFICIENCHY AND SAFETY. MOREOVER, MORE LONG-TERM TRIALS AND STUDIES IN MALES ARE REQUIRED. |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Dose expression | DOSE |