Experiment 352131
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Empty organism |
| Citation | VAN TOL,A: URGERT,R: DE JONG-CAESAR,R: VAN GENT,T: SCHEEK,LM: DE ROOS,B: KATAN,MB:. (1997). THE CHOLESTEROL-RAISING DITERPENES FROM COFFEE BEANS INCREASE SERUM LIPID TRANSFER PROTEIN ACTIVITY LEVELS IN HUMANS.. 132(2) |
| Amount utilized | |
| Compound isolated | |
| Disease | A RANDOMIZED, DOUBLE-BLIND, CROSS-OVER STUDY WAS PERFORMED ON 10 HEALTHLY MALES TO DETERMINE IF COFFEE DITERPENES MAY AFFECT LIPOPROTEIN METABOLISM VIA EFFECTS ON LIPID TRANSFER PROTEINS AND LECITHIN:CHOLESTEROL ACYLTRANSFERASE. AFTER 28 DAYS , CAFESTOL RAISED THE MEAN ACTIVITY OF CHOLESTERYLESTER TRANSFER PROTEIN BY 18% AND PHOSPHOLIPID TRANSFER PROTEIN BY 21%. KAHWEOL HAD NO SIGNIFICANT ADDITIONAL EFFECTS. |
| Dose amount | 64.0 MG |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | DAY |
| Dose expression | DOSE |
| Gender | MALE |