Experiment 352246
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Empty organism |
| Citation | VUTYAVANICH,T: WONGTRA-NGAN,S: RUANGSRI,RA:. (1995). PYRIDOXINE FOR NAUSEA AND VOMITING OF PREGNANCY: A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL.. 173(3) |
| Amount utilized | |
| Compound isolated | |
| Disease | A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY WAS PERFORMED TO DETERMINE THE EFFECTIVENESS OF PYRIDOXINE FOR NAUSEA AND VOMITING OF PREGNANCY. DURING AN 11-MO PERIOD 342 WOMEN AT 17 WK' GESTATION WERE RANDOMIZED TO RECEIVE EITHER ORAL PYRIDOXINE HYDROCHLORIDE, 30 MG PER DAY, OR PLACEBO IN A DOUBLE-BLIND FASHION. PATIENTS GRADED THE SEVERITY OF THEIR NAUSEA BY A VISUAL ANALOG SCALE AND RECORDED THE NO. OF VOMITING EPISODES OVER THE PREVIOUS 24 H BEFORE TREATMENT AND AGAIN DURING 5 CONSECUTIVE DAYS ON TREATMENT. THERE WAS A SIGNIFICATNT DECREASE IN THE MEAN OF POSTTHERAPY MINUS BASELINE NAUSEA SCORES IN THE PYRIDOXINE COMPARED WITH THAT IN THE PLACEBO GROUP (T TEST, P=0.008). THERE WAS ALSO A GREATER REDN. IN THE MEAN NO. OF VOMITING EPISODES, BUT THE DIFFERENCE DID NOT REACH STATISTICAL SIGNIFICANCE (P = 0.0552). PYRIDOXINE IS EFFECTIVE IN RELIEVING THE SEVERITY OF NAUSEA IN EARLY PREGNANCY. |
| Dose amount | 30.0 MG |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN(PREGNANT) |
| Per unit | DAY |
| Dose expression | DOSE |