Experiment 352433
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Plantago ovata (PLANTAGINACEAE) |
| Citation | NORDGAARD,I: HOVE,H: CLAUSEN,MR: MORTENSEN,PB:. (1996). COLONIC PRODUCTION OF BUTYRATE IN PATIENTS WITH PREVIOUS COLONIC CANCER DURING LONG-TERM TREATMENT WITH DIETARY FIBRE (PLANTAGO OVATA SEEDS).. 31(10) |
| Amount utilized | |
| Compound isolated | |
| Disease | TWENTY PATIENTS RESECTED FOR COLERECTAL CANCER WERE TREATED 20 G/DAY OF THE FIBRE PLANTAGO OVATA SEEDS FOR 3 MONTHS, WHICH INCREASED THE INTAKE OF FIBRE BY 17.9+0.8 G/DAY, FROM BASAL LEVELS OF 19.2+1.7 G/DAY; 17 PATIENTS COMPLETED THE STUDY. FAECAL SAMPLES WERE OBTAINED ON EIGHT OCCASIONS, TWICE BEFORE TREATMENT, AND MONTHLY THREE TIMES DURING AND THREE TIMES AFTER TREATMENT. RESULTS: ONE MONTH OF FIBRE THERAPY INCREASED FAECAL CONCENTRATIONS OF BUTYRATE BY 42+12% (FROM 13.2+1.2 TO 19.3+3.0 MMOL/L; P<10-4), ACETATE BY 25+6% (P<10-4), PROPIONATE BY 28+9% (P=0.01), AND TOTAL SCFAS BY 25+6% (P<10-4). CONCENTRATIONS WERE INCREASED DURING THE 3-MONTH FIBRE TREATMENT BUT REVERSED TO PRETREATMENT LEVELS WITHIN 1 TO 2 MONTHS AFTER CESSATION OF FIBRE SUPPLEMENTATION. THE RELATIVE CONCENTRATION (RATIO) OF BUTYRATE WAS NOT ALTERED OWING TO A SIMULTANEOUS INCREASE IN ACETATE AND PROPIONATE. FAECAL PH DECREASED INITIALLY BUT WAS NORMALIZED AFTER 2 MONTHS OF FIBRE SUPPLEMENTS. FIBRE THERAPY INCREAED THE 24-H PRODUCTIONS OF BUTYRATE BY 47+10% (P<10-4) AND ACETATE BY 50+7% (P<10-4) IN 16.6% FAECAL HOMOGENATES WITH ADDED P. OVATA SEED (20 MG/ML), BUT SCFA PRODUCTIONS RETURNED TO PRETREATMENT LEVELS AFTER DISCONTINUATION OF ADDITIONAL FIBRE INTAKES. CONCLUSIONS: ORAL INTAKE OF P. OVATA SEEDS ADAPTED THE COLONIC FLORA TO INCREASE THE PRODUCTION OF BUTYRATE ( AND ACETATE) FROM THIS FIBRE AND INCREASED FAECAL CONCENTRATION OF BUTYRATE BY 42% IN PATIENTS RESECTED FOR COLONIC CANCER. THE EFFECTS DEPENDED ON CONTINUITY OF TREATMENT. |
| Dose amount | 20.0 GM |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | DAY |
| Dose expression | DOSE |
| Extract | SEEDS |
| Gender | GIVEN TO BOTH SEXES |