Experiment 356478
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | INTRAGASTRIC |
| Organism | Teucrium chamaedrys (LAMIACEAE) |
| Citation | LEKEHAL,M: PESSAYRE,D: LEREAU,JM: MOULIS,C: FOURASTE,I: FAU,D:. (1996). HEPATOTOXICITY OF THE HERBAL MEDICINE GERMANDER: METABOLIC ACTIVATION OF ITS FURANO DITERPENOIDS BY CYTOCHROME P450 3A DEPLETES CYTOSKELETON-ASSOCIATED PROTEIN THIOLS AND FORMS PLASMA MEMBRANE BLEBS IN RAT HEPATOCYTES.. 24(1) |
| Amount utilized | |
| Compound isolated | |
| Disease | DECREASED CELL GLUTATHIONE AND CYTO SKELETON-ASSOCIATED PROTEIN THIOLS AND LED TO THE FORMATION OF PLASMA MEMBRANE BLEBS AND CELL DEMISE. |
| Dose amount | 100.0 MCG |
| Number | 2 |
| Qualitative result | ACTIVE |
| Animal | RAT |
| Per unit | ML |
| Dose expression | CONC USED |
| Extract | TERPENOID FRACTION |
| Gender | MALE |