| Disease | TEN HEALTHY HUMAN VOLUNTEERS WERE RECRUITED FOR A FOUR-LIMBED RANDOMIZED CROSSOVER STUDY. THE THREE EXPERIMENTAL LIMBS CONSISTED OF ADMINISTRATION OF 30 ML SYRUP OF IPECAC, AT 5,30 OR 60 MINUTES AFTER INGESTION OF 3900 MG ACETAMINOPHEN AS 12 X
325 MG TABLETS WITH 250 ML ROOM TEMPERATURE WATER. THE FOURTH LIMB SERVED AS CONTROL. BLOOD SAMPLES WERE DRAWN AT 0, 0.5, 1.0, 2.0, 3.0, 4.0, 6.0. AMD 8.0 HOURS AFTER ANALGESIC INGESTION FOR SERUM ACETAMINOPHEN CONCENTRATION DETERMINATION BY
HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY. REPEATED MEASURES ANOVA AND TUKEY'S HSD TESTS WERE USED FOR GROUP COMPARISONS. RESULTS: THE AREA UNDER SERUM CONCENTRATION VS TIME CURVE WAS (MEAN(DL)SD) 206 (DL)48, 67 (DL)37, 183 (DL)78, AND 162 (DL)47
MG/L FOR CONTROL, 5, 30, AND 60 MINUTES, RESPECTIVELY. THIS CORRESPONDS TO DECREASES IN BIOAVAILABILITY OF 67, 11, AND 21%. ONLY THE 5-MINUNTE GROUP DIFFERED SIGNIFICANTLY FROM CONTROL (P < 0.05). |