Experiment 363688
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Organism | Citrus paradisi (RUTACEAE) |
| Citation | SCHMIEDLIN-REN,P: EDWARDS,DJ: FITZSIMMONS,ME: HE,K: LOWN,KS: WOSTER,PM: RAHMAN,A: THUMMEL,KE: FISHER,JM: HOLLENBERG,PF: WATKINS,PB:. (1997). MECHANISMS OF ENHANCED ORAL AVALABILITY OF CYP3A4 SUBSTRATES BY GRAPEFRUIT CONSTITUENTS. DECREAED ENTEROCYTE CYP3A4 CONCENTRATION AND MECHANISM-BASED INACTIVATION BY FURANOCOUMARINS.. 25(11) |
| Amount utilized | |
| Compound isolated | |
| Disease | CAUSED RAPID FALL IN CATALYTIC ACTIVITY AND IMMUNOREACTIVITY OF CYP3A4 ENZYME, APPARENTLY SECONDARY TO ACCELERATED DEGRADATION. GREATEST ACTIVITY ATTRIBUTED TO 6',7'-DIHYDROXY-BERGAMOTTIN. |
| Dose amount | 0.1% |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | CELL CULTURE |
| Dose expression | CONC USED |
| Extract | JUICE |