| Pharmacology |
|
| Administration route | ORAL |
| Organism | Plantago ovata (PLANTAGINACEAE) |
| Citation | OLSON,BH: ANDERSON,SM: BECKER,MP: ANDERSON,JW: HUNNINGHAKE,DB: JENKINS,DJA: LA ROSA,JC: RIPPE,JM: ROBERTS,DCK: STOY,DB: SUMMERBELL,CD: TRUSWELL,AS: WOLEVER,TMS: MORRIS,DH: FULGONI III,VL:. (1997). PSYLLIUM-ENRICHED CEREALS LOWER BLOOD TOTAL CHOLESTEROL AND LDL CHOLESTEROL, BUT NOT HDL CHOLESTEROL, IN HYPERCHOLESTEROLEMIC ADULTS: RESULTS OF A META-ANALYSIS.. 127(10) |
| Amount utilized | |
| Compound isolated | |
| Disease | A META-ANALYSIS OT DETERMINE THE EFFECT OF CONSUMPTION OF PSYLLIUM-ENRICHED CEREAL PRODUCTS ON BLOOD TOTAL CHOLESTEROL (TC), LDL CHOLESTEROL (LDL-C)- AND HDL CHOLESTEROL (HDL-C) LEVELS AND TO ESTIMATED THE MAGNITUDE OF THE EFFECT AMONG 404
ADULTS WITH MILD TO MODERATE HYPERCHOLESTEROEMIA WHO CONSUMED A LOW FAT DIET. PUBLISHED AND UNPUBLISHED STUDIES WERE REVIEWED BY ONE AUTHOR AND CONSIDERED ELIGIBLE FOR INCLUSION IN THE META-ANALYSIS IF THEY WERE CONDUCTED IN HUMAN, WERE
RANDOMIZED, CONTROLLED EXPERIMENTS, AND INCLUDED A CONTROL GROUP THAT ATE CEREAL PROVIDING <3 G SOLUBLE FIBER/D. EIGHT PUBLISHED AND FOUR UNPUBLISHED STUDIES, CONDUCTED IN FOUR COUNTRIES, MET THE CRITERIA. ANALYSIS OF A LINEAR MODEL WAS
PERFORMED, CONTROLLING FOR SEX AND AGE. FEMALE SUBJECTS WERE DIVIDED INTO TWO GROUPS TO PROVIDE A ROUGH ESTIMATE OF THE EFFECT OF MENOPAUSAL STATUS (PREMENOPAUSAL =<50Y, POSTMENOPAUSAL =>50 Y) ON BLOOD LIPIDS. THE META-ANLAYSIS SHOWED THAT
SUBJECTS WHO CONSUMED A PSYLLIUM CEREAL HAD LOWER TC AND LDL-C CONCENTRATIONS [DIFFERENCES OF 0.31 MMOL/L (5%) ON 0.35 MMOL/L (9%), RESPECTIVELY] THAN SUBJECTS WHO ATE A CONTROL CEREAL; HLD-C CONCENTRATIONS WERE UNAFFECTED IN SUBJECTS EATING
PSYLLIUM CEREAL. THERE WAS NO EFFECT OF SEX, AGE OR MENOPAUSAL STATUS ON BLOOD LIPIDS. RESULTS INDICATE THE CONSUMING A PSYLLIUM-ENRICHED CEREAL AS PART OF A LOW FAT DIET IMPROVES THE BLOOD LIPID PROFILE ON HYPERCHOLESTEROLEMIC ADULTS OVER
THAT WHICH CAN BE ACHIEVED WITH A LOW FAT DIET ALONE. |
| Dose amount | 3.0 GM |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | DAY |
| Dose expression | DOSE |
| Extract | HUSKS |
| Gender | GIVEN TO BOTH SEXES |