Experiment 366988

Details

PropertyValue
Pharmacology
Administration routeORAL
OrganismSerenoa repens (ARECACEAE)
CitationDE BERNARDI DI VALSERRA,M: TRIPODI,AS: CONTOS,S: GERMOGLI,R:. (1994). SERENOA REPENS CAPSULES: A BIOEQUIVALENCE STUDY.. 15(1)
Amount utilized
Compound isolated
DiseaseA BIOEQUIVALENCE STUDY OF A NEW SERENOA REPENS 320 MG CAPSULE FORMULATION WAS CARRIED OUT IN 12 HEALTHY MALE SUBJECTS IN ORDER TO EVALUATE PLASMA CONCENTRATION/TIME CURVE AND TO PERFORM STANDARD BIOEQUIVALENCE ANALYSIS IN COMPARISON TO A REFERENCE 16O MG PREPARATION. THIS OPEN, RANDOMIZED STUDY HAD A SINGLE-DOSE (320 MG), CROSSOVER DESIGN AND CONSISTED OF TWO TRIAL PERIODS SEPARATED BY A ONE-WEEK WASH-OUT PERIOD. THE PLASMA CONCENTRATION-TIME PROFILE OF BOTH PREPARATIONS WAS NEARLY IDENTICAL. THE RATIO OF AUC (EXTENT OF ABSORPTION) WAS 1.026 (90% - CONFIDENCE INTERVAL 0.992-1.062), THE RATIO OF CMAX (RATE OF ABSORPTION) WAS 0.982 (90%-CONFIDENCE INTERVAL 0.930-1.038), THE DIFFERENCE OF TMAX (RATE OF ABSORPTION) WAS 0 HOURS (90%-CONFIDENCE INTERVAL FROM 0 TO 0.25 HOURS.
Dose amount320.0 MG
Number1
Qualitative resultACTIVE
AnimalHUMAN ADULT
Per unitDAY
Dose expressionDOSE
ExtractHEXANE EXT
GenderMALE