Experiment 369675
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Serenoa repens (ARECACEAE) |
| Citation | BRAECKMAN,J: BRUHWYLER,J: VANDEKERCKHOVE,K: GECZY,J:. (1997). EFFICACY AND SAFETY OF THE EXTRACT OF SERENOA REPENS IN THE TREATMENT OF BENIGN PROSTATIC HYPERPLASIA: THERAPEUTIC EQUIVALENCE BETWEEN TWICE AND ONCE DAILY DOSAGE FORMS.. 11(8) |
| Amount utilized | |
| Compound isolated | |
| Disease | THE EFFICACY AND SAFETY OF TWO DOSAGE FORMS(160 MG B.I.D. AND 320 MG O.D) OF THE EXTRACT OF SERENOA REPENS WERE COMPARED DURING A 1-YEAR TREATMENT IN 132 PATIENTS SUFFERING FROM BENIGN PROSTATIC HYPERPLASIA (BPH). BOTH DOSAGE FORMS INDUCED A SIGNIFICANT IMPROVEMENT IN THE EFFICACY VARIABLES: INTERNATIONAL PROSTATE SYMPTOM SCORE(60% AFTER 1 YEAR), QUALITY OF LIFE SCORE(85% OF PATIENTS WERE SATISFIED AFTER 1 YEAR OF TREATMENT), PROSTATIC VOLUME(12% AFTER 1 YEAR), MAXIMUM FLOW RATE (22% AFTER 1 YEAR), MEAN FLOW RATE(17% AFTER 1 YEAR) AND RESIDUAL URINARY VOLUME(16% AFTER 1 YEAR). NO SIGNIFICANT DIFFERENCES WERE FOUND BETWEEN THE TWO DOSAGE FORMS. THE PERCENTAGE OF PATIENTS OR INVESTIGATORS EVALUATING THAT THE TREATMENT HAD A MEDIUM OR BAD TOLERANCE WAS NEVER SUPERIOR TO 4%. NINETEEN SIDE EFFECTS WERE OBSERVED IN 16 PATIENTS(12.1%), 8 PATIENTS IN EACH GROUP. THE MAJORITY OF THESE SIDE EFFECTS(AT LEAST 75%) WERE RELATED TO THE NATURAL EVOLUTION OF THE DISEASE ITSELF RATHER THAN TO THE MEDICATION. WE CONCLUDE THAT THE EXTRACT OF SERENOA REPENS IN ITS TWO DOSAGE FORMS IS A SAFE AND EFFECTIVE TREATMENT FOR THE MICTIONAL PROBLEMS ASSOCIATED WITH BPH. CONSEQUENTLY, IT APPEARS TO OFFER A POTENTIAL PHARMACOLOGIC ALTERNATIVE CAPABLE OF IMPROVING BPH SYMPTOMS IN PATIENTS WITH MILD-TO-MODERATE DISEASE. |
| Dose amount | 320.0 MG |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | DAY |
| Dose expression | DOSE |
| Extract | HEXANE EXT |
| Gender | MALE |