Experiment 370593
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | SC |
| Organism | Empty organism |
| Citation | AKINGBEMI,BT: AIRE,TA: OKE,BO:. (1997). THE INFLUENCE OF PROTEIN MALNUTRITION ON THE ANTIFERTILITY ACTION OF GOSSYPOL IN THE TRYPANOSOMA BRUCEI-INFECTED RAT: SOME ULTRASTRUCTURAL OBSERVATIONS FROM THE TESTIS.. 11(4) |
| Amount utilized | |
| Compound isolated | |
| Disease | THE TESTES OF ADULT MALE WISTAR RATS THAT WERE VARIOUSLY PROTEIN MALNURISHED, GOSSYPOL TREATED, AND/OR TRYPANOSOME INFECTED (TRYPANOSOMA BRUCEI) WERE EVALUATED ULTRASTRUCTURALLY. THE FINDINGS INCLUDED SEVERAL NECROTIC GERM CELLS IN THE SEMINIFEROUS EPITHELIUM AND FOCAL DEGENERATION OF SERTOLI CELLS. LEYDIG CELLS SHOWED A REMARKABLE PAUCITY OF SMOOTH ENDOPLASMIC RETICULUM, AND AGGREGATION OF MITOCHONDRIA. THESE OBSERVATIONS WERE PREVALENT IN THOSE ANIMALS THAT WERE SIMULTANEOUSLY PROTEIN-MALNURISHED/GOSSYPOL TREATED/TRYPANOSOME INFECTED, AND WERE EITHER ABSENT OR MARKEDLY REDUCED IN THE OTHER GROUPS. THESE STRUCTURAL ALTERATIONS ARE PROBABLY RELATED TO INCREASED GOSSYPOL AVAILABILITY TO THE TESTIS AND/OR REPRESENT THE ADDITIVE EFFECTS OF GOSSYPOL AND TRYPANOSOMES. SUCH TISSUE CHANGES COULD COMPROMISE SPERMATOGENESIS IN AFFECTED ANIMALS, AND SUGGEST THAT TRYPANOSOME INFECTIONS MAY EXACERBATE TESTICULAR LESIONS IN THE GOSSYPOL-TREATED RAT. |
| Dose amount | 20.0 MG |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | RAT |
| Per unit | KG |
| Dose expression | DOSE |
| Gender | MALE |