Experiment 370766
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | EXTERNAL |
| Organism | Empty organism |
| Citation | PHELPS,WC: LOBE,DC:. (1994). TOPICAL PHARMACEUTICALS CONTAINING VINCA ALKALOIDS FOR THE TREATMENT OF PAPILLOMARVIRUS INFECTION.. () |
| Amount utilized | |
| Compound isolated | |
| Disease | CERTAIN KNOWN VINCA ALKALOIDS ARE USED IN THE PREPN. OF MEDICAMENTS FOR TREATMENT OR PROPYLAXIS OF PAPILLOMAVIRUS INFECTION. A CREAM CONTAINED VINORELBINE (I) 1,00, GLYCEROL 2.00, CETOSTERALYL ALC. 6.75, NA LAURYL SULFATE 0.75, WHITE SOFT PARAFFIN 12.5 LIQ. PARAFFIN 5.00, CHOLOCRESOL 0.10, AND WATER 100.00G. FRESH TISSUE FROM HUMAN CUTANEOUS OR MUSCOSAL WARTS WAS GRAFTED ON TO A WELL VASCULARIZED BED IN AN IMPLANTATION CHAMBER ON THE DORSUM OF IMMUNO-COMPROMISED MICE. AFTER 1 WK POST GRAFTING THE HUMAN WART TISSUE GRAFTS WERE TREATED TOPICALLY WITH AN AQ. I CREAM (DAYS 7 AND 9) AND NECROPSIDED AT 3 WK. GROWTH OF HUMAN PAPILLOMA VIRUS WAS INHIBITED BY 100%. |
| Dose amount | 1.0% |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | MOUSE |
| Dose expression | CONC USED |