Experiment 370863
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Citrus paradisi (RUTACEAE) |
| Citation | DUCHARME,MP: PROVENZANO,R: DEHOORNE,-SMITH,M: EDEARDS,DJ:. (1993). TROUGH CONCENTRATIONS OF CYCLOSPORINE IN BLOOD FOLLOWING ADMINISTRATION WITH GRAPEFRUIT JUICE.. 36(5) |
| Amount utilized | |
| Compound isolated | |
| Disease | GRAPEFRUIT JUICE INCREASED THE BIOAVAILABILITY OF DRUG CYCLOSPORIN IN 11 KIDNEY TRANSPLANTATION PATIENTS. RESULTS USGGEST THAT THE JUICE INHIBITS METABOLISM OF THE DRUG BY INHIBITION OF CYTOCHROME P450 ISOENZYME CYP3A4. |
| Dose amount | 240.0 ML |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HAMSTER(OVARIECTOMIZED) |
| Per unit | DAY |
| Dose expression | DOSE |
| Extract | FRUIT JUICE |
| Gender | GIVEN TO BOTH SEXES |