Experiment 371054
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Citrus paradisi (RUTACEAE) |
| Citation | CHENG,KL: NAFZIGER,AN: PELOQUIN,CA: AMSDEN,GW:. (1998). EFFECT OF GRAPEFRUIT JUICE ON CLARITHROMYCIN PHARMACOKINETICS.. 42(4) |
| Amount utilized | |
| Compound isolated | |
| Disease | TO INVESTIGATE WHETHER GRAPEFRUIT JUICE INHIBITS THE METABOLISM OF CLARITHROMYCIN, 12 HEALTHY SUBJECTS WERE GIVEN WATER OF GRAPEFRUIT JUICE BEFORE AND AFTER CLARITHROMYCIN DOSE OF 500 MG IN A RANDOMIZED CROSSOVER STUDY. ADMINISTRATION OF GRAPE FRUIT JUICE INCREASED THE TIME OF PEAK CONCENTRATION OF BOTH CLARITHROMYCIN (82 DL 35 VERSUS 148 DL 83 MIN; P=0.02) AND 14-HYDROXYCLARITHROMYCIN (84 DL 38 MIN VERSUS 173 DL; P=0.01) BUT DID NOT AFFECT OTHER PHARMACOKINETIC PARAMETERS. |
| Dose amount | 240.0 ML |
| Number | 1 |
| Qualitative result | . |
| Animal | HUMAN ADULT |
| Dose expression | DOSE |
| Extract | JUICE |
| Gender | GIVEN TO BOTH SEXES |