Experiment 371983
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Empty organism |
| Citation | ADLER,Y: GUINDO,J: FINKELSTEIN,Y: KHOURI,A: ASSALI,A: BAYES-GENIS,A: DE LUNA,A:. (1998). COLCHICINE FOR LARGE PERICARDIAL EFFUSION.. 21(2) |
| Amount utilized | |
| Compound isolated | |
| Disease | ON THE BASIS OF REPORTED EXPERIENCE WITH COLCHICINE FOR RECURRENT PERICARDITIS, WE ADMINISTERED COLCHICINE TO TWO PATIENTS WITH LARGE PERICARDIAL EFFUSIONS COMPLICATING IDIOPATHIC PERICARDITIS. THE FIRST WAS A 26 YEAR OLD MALE WHO SHOWED CLINICAL DETERIORATION FOLLOWING EMERGENCY PERICARDIOCENTESIS AND ASPIRIN (3 G.DAY) FOR 10 DAYS; THE SECOND WAS A 2 YEAR OLD GIRL WHO WAS UNSUCCESSFULLY TREATED WITH ASPIRIN (100 MG/KG/DAY) FOR 2 WEEKS, FOLLOWED BY CORTICOSTEROIDS FOR 7 MONTHS. ADMINISTRATION OF COLCHICINE (1 MG/DAY) INSTEAD OF ASPIRIN IN THE FIRST CASE, AND WITH A RAPID TAPERING-OFF OF THE CORTICOSTEROIDS IN THE SECOND CASE, LED TO COMPLETE REGRESSION OF THE PERICARDIAL EFFUSION ON ECHOCARDIOGRAPHY WITHIN 1 WEEK AND 1 MONTH, RESPECTIVELY. COLCHICINE WAS DISCONTINUED AFTER 1 MONTH IN THE FIRST PATIENT AND WAS CONTINUED FOR 6 MONTHS IN THE CHILD. NEITHER HAS HAD A RECURRENCE AT 24 AND 6 MONTHS OF FOLLOW-UP, RESPECTIVELY. NO SIDE EFFECTS OF COLCHICINE WERE OBSERVED. WE CONCLUDE THAT COLCHICINE MAY BE EFFECTIVE IN THE TREATMENT OF LARGE PERICARDIAL EFFUSION WHEN THERAPY WITH NONSTEROIDAL ANTI-INFLAMMATORY DRUGS AND/OR CORTICOSTEROIDS FAILS. |
| Dose amount | 1.0 MG |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | DAY |
| Dose expression | DOSE |
| Gender | GIVEN TO BOTH SEXES |