Experiment 372320
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | INTRAVESICULAR |
| Organism | Empty organism |
| Citation | DASGUPTA,P: CHANDIRAMANI,V: PARKINSON,MC: BECKETT,A: FOWLER,CJ:. (1998). TREATING THE HUMAN BLADDER WITH CAPSAICIN: IS IT SAFE?. 33(1) |
| Amount utilized | |
| Compound isolated | |
| Disease | BETWEEN 1991 AND 1996, 20 PTS (9 MALES, 11 FEMALES; MEAN AGE 52.5 YRS. RANGE 40-70 YRS) WITH INTRACTABLE DETRUSOR HYUPERREFLEXIA HAVE HAD REPEATED INSTILLATIONS OF INTRAVESICAL CAPSAICIN (1-2 MMOL/L). THE NUMBER OF TREATMENTS PER PTS VARIED BETWEEN 1 AND 17 (TOTAL-82; AVERAGE 6/PT). THE SURVEILLANCE PROGRAMME INVOLVED REPEATED FLEXIBLE CYSTOSCOPY AND BLADDER BIOPSIES BEFORE AND AFTER CAPSAICIN. CRYOSTAT SECTIONS WERE STRAINED WITH HAEMTOXYLIN-EOSIN AND EXAMINED BY LIGHT MICROSCOPY. NONE OF THE BLADDER BIOPSIES HAVE SHOWN METAPLASIA, DYSPLASIA, FLAT CARCINOMA IN SITU, PAPILLARY OR SOLID INVASIVE CANCER. NO PRE-MALIGNANT OF MALIGNANT CHANGE HAS BEEN FOUND IN BIOPSIES OF PATIENTS WHO HAD REPEATED CAPSAICIN INSTILLATIONS FOR UP TO 5 YRS. |
| Dose amount | 0.3 GM |
| Number | 1 |
| Qualitative result | INACTIVE |
| Animal | HUMAN ADULT |
| Per unit | LITER |
| Dose expression | DOSE |
| Gender | GIVEN TO BOTH SEXES |