Experiment 374158
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Empty organism |
| Citation | DAHLSTROM,B: MELLSTRAND,T: LOFDAHL,CG: JOHANSSON,M:. (1982). PHARMAKOKINETIC PROPERTIES OF NOSCAPINE.. 22() |
| Amount utilized | |
| Compound isolated | |
| Disease | NOSCAPINE WAS ADMINISTERED TO FIVE HEALTHY VOLUNTEERS IN A RANDOMIZED CROSSOVER DESIGN, AS AN INTRAVENOUS INFUSION OF 66 MG, AND AS AN ORAL 150 MG DOSE OF EITHER RAPIDLY DISSOLVING TABLETS OR A TABLET CONTAINING ION EXCHANGE RESIN-BOUND NOSCAPINE. THE ABSOLUTE ORAL BIOAVAILABILITY WAS 30% WITH A 3.5-FOLD INTERINDIVIDUAL VARIATION. THERE WAS NO PHARMACOKINETIC EVIDENCE TO SUPPORT A PROLONGED ACTION OF THE ION EXCHANGE RESIN TABLET. |
| Dose amount | 150.0 MG |
| Number | 2 |
| Qualitative result | . |
| Animal | HUMAN ADULT |
| Dose expression | DOSE |
| Gender | GIVEN TO BOTH SEXES |