| Disease | A DOUBLE BLIND, RANDOMIZED CROSS OVER STUDY WITH 14 NORMAL VOLUNTEERS, TO EVALUATE THE EFFECT OF THIS DOSE OF PSYLLIUM ON POSTRADIAL SERUM GLUCOSE, TRIGLYCERIDES AND INSULIN LEVELS, AND ON GASTRIC FULLNESS, HUNGER FEELING AND FOOD INTAKE. GASTRI
EMPTYING WAS MEASURED USING A STANDARD DOUBLE-RADIOLABELED 450 KEAL MEAL AND FEELINGS BY VISUAL ANALOGIC SCALES. THE POSTPRANDIAL SERUM GLUCOSE, TRIGLYCERIDES AND INSULIN LEVELS WERE ALSO DETERMINED. NO DELAY IN THE GASTRIC EMPTYING OF THE
SOLID AND LIQUID PHASES OF THE MEAT WAS OBSERVED WITH PSYLLIUM. AFTER THE MEAL, HUNGER FEELINGS AND ENERGY INTAKE WERE SIGNIFICANTLY LOWER DURING THE PSYLLIUM SESSION THAN DURING THE PLACEBO SESSION (13% AND 17% LOWER RESPECTIVELY: P<0.05).
POSTPRANIDAL INCREASE IN SERUM GLUCOSE, TRIGLYCERIDES AND INSULIN LEVELS WAS LESS WITH PSYLLIUM THAN WITH PLACEBO (P<0.05). PSYLLIUM REDUCED HUNGER FEELINGS AND ENERGY INTAKE IN NORMAL VOLUNTEERS AT REASONABLE DOSE AND WITHOUT REQUIRING MIXING
WITH THE MEAL. IT DOES NOT ACT BY SLOWING DOWN THE GASTRIC EMPTYING OF HYDROSOLUBLE NUTRIENTS, BUT BY INCREASE FIN THE TIME ALLOWED FOR INTESTINAL ABSORPTION, AS SUGGESTED BY THE FLATTENING OF THE POSTPRANDIAL SERUM GLUCOSE. INSULIN AND
TRIGLYCERIDES CURVES. |