Experiment 375266
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Aesculus hippocastanum (HIPPOCASTANACEAE) |
| Citation | REHN,D: UNKAUF,M: KLEIN,P: JOST,V: LUCKER,PW:. (1996). COMPARATIVE CLINICAL EFFICACY AND TOLERABILITY OF OXERUTINS AND HORSE CHESTNUT EXTRACT IN PATIENTS WITH CHRONIC VENOUS ISUFFICIENCY.. 46(1) |
| Amount utilized | |
| Compound isolated | |
| Disease | RANDOMIZED DOUBLE-BLIND COMPARISON STUDY ASSESSED THE EFFECT OF A STANDARDIZED SEED EXTRACT AND OXERUTINS (O-(BETA-HYDROXYETHYL)-RUTINOSIDES) IN THE TREATMENT OF 137 POSTMENAPAUSAL WOMEN IN CVI STAGE II. FOLLOWING ONE WEEK PLACEBO RUN-IN, THE PATIENTS WERE TREATED WITH EITHER 1000 MG/DAY OXERUTINS, 600 MG/DAY STANDARDIZED EXTRACT OR 1000 MG/DAY OXERUTINS FOR 4 WEEKS THEN 500 MG/DAY OXENUTINS FOR 12 WEEKS AND THEN OBSERVATION FOR A FURTHER 6 WEEKS. PATIENTS TREATED WITH 1000 MG/DAY OF OXERUTINS AND A GREATER DECREASE IN LEG VOLUME REDUCTION THAN PATIENTS TREATED WITH ETHER THE STANDARDIZED EXTRACT OR 1000 MG/DAY (4 WEEKS) AND THE 500 MG/DAY OXERUTINS (12 WEEKS). |
| Dose amount | 600.0 MG |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | DAY |
| Dose expression | DOSE |
| Extract | HYDRO-ALCOHOLIC EXT |
| Gender | GIVEN TO BOTH SEXES |