Experiment 375308

Worktypes

PHARMACOLOGY OF COMPOUND - IN VIVOEFFECTS DUE TO A COMBINATION OF DRUGSANTICANCER AND/OR CYTOTOXICITY MARKER CODE

Compounds isolated

BRYOSTATIN 1

Alerts

A MIXTURE OF PURE COMPOUNDS WAS USED TO OBTAIN THE REPORTED EFFECT.

Details

PropertyValue
Pharmacology
ANTITUMOR ACTIVITY
Administration routeIP
OrganismEmpty organism
CitationAL-KATIB,AM: SMITH,MR: KAMANDA,WS: PETTIT,GR: HAMDAN,M: NOHAMED,AN: CHELLADURAI,B: MOHAMMAD,RM:. (1998). BRYOSTATIN 1 DOWN-REGULATES MDR 1 AND POTENTIATES VINCRISTINE CYTOTOXICITY IN DIFFUSE LARGE CELL LYMPHOMA XENOGRAFTS.. 4(5)
Amount utilized
Compound isolated
DiseaseANIMALS WERE GIVEN COMBINATION TREATMENT WITH VINCRISTINE TO INHIBIT GROWTH OF TUMOR FROM PATIENT WITH DRUG-ARESISTANT NON-HODGKIN'S LYMPHOMA.
Dose amount75.0 MCG
Number3
Qualitative resultACTIVE
AnimalMOUSE
Per unitKG
Dose expressionDOSE
GenderFEMALE