Experiment 376646
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | IP |
| Organism | Artocarpus altilis (MORACEAE) |
| Citation | WILLIAMS,LAD: FLETCHER,CK: GARDNER,MT: SINGH,PAD: CHOO-KANG,E: RICKARDS,E:. (1993). TOXIC EFFECTS OF A NONPOLAR EXTRACT OF THE LEAVES OF ARTOCARPUS ALTILIS (PARK) FOLLOWING SUBACUTE ADMINISTRATION TO RATS.. 122(1) |
| Amount utilized | |
| Compound isolated | |
| Disease | L.P. INJECTION OF HEXANE-SOL. COMPOUNDS FROM THE LEAVES OF A.ALTILIS LOWERED THE FOLLOWING HEMATOL. PARAMETERS IN RATS: WHITE BLOOD CELL COUNTS, THROMBOCYTES, AND HB SIGNIFICANTLY (P<0.05). PLASMA ANAL. ALSO REVEALED A SIGNIFICANT LOWERING OF TOTAL BILIRUBIN, ASPARTATE AMINOTRANSFERASE, AND ALK. PHOSPHATASE. HISTOL. AXAMN. OF THE LIVER, KIDNEY, AND LUNG REVEALED EXTENSIVE ERYTHROCYTE AGGREGATION. PROMINENE PERIBRONCHIAL AND PARIVASCULAR LYMPHATIC HYPERPLASIA WERE SEEN IN THE LUNGS. MARKED FOLLICULAR HYPERPLASIA WERE SEEN IN THE SPLEEN. THIS REPORT HAS HIGHLIGHTED SOME OF THE TOXIC EFFECTS OF THE OIL OF THE BREADFRUIT LEAVES. |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | RAT |
| Dose expression | DOSE |
| Extract | HEXANE EXT |