Experiment 378627
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Oenothera biennis (ONAGRACEAE) |
| Citation | BIAGI,PL: BORDONI,A: HARELIA,S: CELADON,M: ARICCI,GP: CANNELLA,V: PATRIZI,A: SPECCHIA,F: MASI,M:. (1994). THE EFFECT OF GAMMA-LINOLENIC ACID ON CLINICAL STATUS, RED CELL FATTY ACID COMPOSITION AND MEMBRANE MICROVISCOSITY IN INFANTS WITH ATOPIC DERMATATIS.. 20(2) |
| Amount utilized | |
| Compound isolated | |
| Disease | A DOUBLE BLIND PLACEBO-CONTROLLED STUDY OF TWO DOSES OF GAMMA-LINOLENIC ACID, PROVIDED BY EVENING PRIMROSE OIL, IN 51 CHILDREN WITH ATOPIC DERMATITIS WAS PERFORMED: 1) TO EXAMINE THE EFECT OF GAMMA-LINOLENIC ACID ADMINISTRATION ON THE CLINICAL STATIS OF CHILDREN WITH ATOPIC DERMATITIS AND ABNORMALITIES OF IGE-MEDIATED IMMUNE RESPONSES COMPARED TO THOSE WITHOUT SUCH IGE ABNORMALITIES: 2) TO INVESTIGATE THE EFFECT OF GAMMA-LINOLENIC ACID ON RED CELL FATTY ACID COMPOSITION AND: 3) TO ASSESS WHETHER TREATMENT WITH GAMMA-LINOLENIC ACID INDUCED CHANGES IN RED CELL MEMBRANE MICROVISCOSITY. A SIGNIFICANT IMPROVEMENT IN THE OVERALL SEVERITY OF THE CLINICAL CONDITION WAS SEEN IN CHILDREN TREATED WITH GAMMA-LINOLENIC ACID, INDEPENDENT OF WHETHER THE CHILDREN HAD MANIFESTATIONS OF IGE-MEDIATED ALLERGY. FURTHERMORE, GAMMA-LINOLENIC ACID TREATMENT INCREASED THE PERCENTAGE CONTENT OF N-6 FATTY ACIDS IN ERYTHROCYTE CELL MEMBRANE; THIS INCREASE WAS MORE MARKED IN THE MEMBRANES OF CHILDREN TREATED WITH HIGH DOSES OF EPO. |
| Dose amount | 0.5 GM |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN CHILD |
| Per unit | KG |
| Dose expression | DOSE |
| Extract | SEED OIL |
| Gender | GIVEN TO BOTH SEXES |