| Disease | TWENTY-TWO HEALTHY MALE SUBJECTS RECEIVED A SINGLE 100 MG DOSE OF ITRACONAZOLE WITH EITHER 350 ML GRAPEFRUIT JUICE, ORANGE JUICE OR MINERAL WATER. PLASMA CONCENTRATIONS OF ITRACONAZOLE WERE MEASURED BY HPLC, AND PHARMACOKINETIC PARAMETERS; CMAX,
TMAX, T 1/2, AUC, AND AUC CORRECTED BY HUMAN BODY SURFACE AREA: AUC/S, WERE CALCULATED. RESULTS: GRAPEFRUIT JUICE HAD NO EFFECT ON ANY PHARMACOKINETIC PARAMETER OF ITRACONAZOLE. HOWEVER, T 1/2, AUC, OR AUC/S WERE SIGNIFICANTLY DECREASED IN
ORANGE JUICE TREATMENT GROUP COMPARED TO THOSE IN MINERAL WATER GROUP (AVERAGE DECREASE 56%, P<0.01, 41%, P<0.05, AND 43%, P<0.05, RESPECTIVELY). CONCLUSION: COADMINISTRATION OF GRAPEFRUIT JUICE DID NOT AFFECT ANY PHARMACOKINETIC PARAMETER OF
INTRACONAZOLE WHILE THAT OF ORANGE JUICE DECREASED THE PARAMETERS OF T 1/2, AUC, AND AUC/S OF THE DRUG. |