Experiment 387870
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Oenothera biennis (ONAGRACEAE) |
| Citation | MARTENS-LOBENHOFFER,J: MEYER,FP:. (1998). PHARMACOKINETIC DATA OF GAMMA-LINOLENIC ACID IN HEALTHY VOLUNTEERS AFTER THE ADMINISTRATION OF EVENING PRIMROSE OIL (EPOGAM).. 36(7) |
| Amount utilized | |
| Compound isolated | |
| Disease | AN INVESTIGATION OF THE SERUM LEVEL-TIME COURSES OF 8 FATTY ACIDS AFTER THE ADMINISTRATION OF EPOGAM, A PREPARATION OF EVENING PRIMROSE OIL WHICH CONTAINS GAMMA-LENOLEIC ACID AS AN ACTIVE INGREDIENT. FROM 6 VOLUNTEERS, SERUM CONCENTRATION TIME CURVES OF GAMMA-LINOLEIC ACID AND 7 OTHER FATTY ACIDS WERE PROFILED 24 H WITH AND WITHOUT THE ADMINISTRATION OF EPOGAM. 6 CAPSULES OF EPOGAM WERE ADMINISTERED TO EACH SUBJECT IN THE MORNING AT 7:00 AND FURTHER 6 CAPSULES IN THE EVENING AT 19:00. ON THE DAYS OF INVESTIGATION THE VOLUNTEERS HAD A DIET OF LOW FAT MEALS. THE SERUM CONCENTRATIONS OF THE FATTY ACIDS WERE DETERMINED AS THEIR METHYL ESTERS BY MEANS OF GAS CHROMATOGRAPHY MASS SPECTROMETRY, GAMMA-LINOLENIC ACID SHOWS AN ABSORPTION-ELIMINATION PATTERN AFTER THE ADMINISTRATION OF EPOGAM AND ITS AUC2RTH AND CMAX ARE SIGNIFICANTLY INCREASED OVER THE BASELINE VALUES. AFTER THE EVENING ADMINISTRATION, TMAX IS SHORTER(2.7 DL 1.2 H) THAN AFTER THE MORNING ADMINISTRATION (4.4 DL 1.9 H). THE OTHER FATTY ACIDS SHOW NO SIGNIFICANT INCREASE IN THEIR CONCENTRATIONS, ESPECIALLY DIHOMO-GAMMA-LINOLEIC ACID AND ARACHIDONIC ACID, WHICH ARE METABOLIC PRODUCTS OF GAMMA-LINOLENIC ACID. CONCLUSIVELY, AN EFFECT OF THE ADMINISTRATION OF GAMMA-LINOLENIC ACID ON THE SERUM CONCENTRATIONS OF DIHOMO-GAMMA-LINOLENIC ACID AND ARACHIDONIC ACID AND, THEREFORE, ON THE BIOSYNTHESIS OF PROSTAGLANDIN PGE1 AND PGE2 COULD NOT ONLY CLEARLY BE ESTABLISHED IN HEALTHY VOLUNTEERS. FURTHER INVESTIGATIONS WILL SHOW IF THERE IS A SIGNIFICANT EFFECT IN PATIENTS SUFFERING FROM ATOPIC ECZEMA. |
| Dose amount | 6.0 GM |
| Number | 2 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | PERSON |
| Dose expression | DOSE |
| Extract | SEED OIL |
| Gender | GIVEN TO BOTH SEXES |