Experiment 387897
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Hypericum perforatum (CLUSIACEAE) |
| Citation | CZEKALLA,J: GASTPAR,M: HUBNER,WD: JAGER,D:. (1997). THE EFFECT OF HYPERICUM EXTRACT ON CARDIAC CONDUCTION AS SEEN IN THE ELECTROCARDIOGRAM COMPARED TO THAT OF IMIPRAMINE.. 30() |
| Amount utilized | |
| Compound isolated | |
| Disease | THE ELECTROCARDIOGRAPHIC EFFECTS OF HIGH-DOSE HYPERICUM EXTRACT WERE COMPARED TO THE EFFECTS OF IMIPRAMINE HYDROCHLORIDE ON ECG RECORDINGS IN A RANDOMIZED, DOUBLE-BLIND, MULTICENTER TREATMENT STUDY OF 209 PATIENTS SUFFERING FROM DEPRESSION. ECGS WERE RECORDED BEFORE AND AFTER SIX-WEEK TREATMENT PEROID WITH EITHER HYPERICUM EXTRACT OR IMIPRAMINE IN THE FIRST ECG ANALYSIS COMPAIRING HIGH DOSE HYPERIMUM EXTRACT WITH IMIPRAMINNE, A PROLONGATION OF CONDUCTION INTERVALS PR, QRS AND QTC WAS FOUND FOR IMIPRAMINE. IN CONTRAST, A SMALL ACCELERATION OF CONDUCTION WAS SEEN FOR THE HIGH DOSE HYPERICUM EXTRACT. THE COMPARISON OF ECGS AT THE BEGINNING AND AFTER SIX WEEKS OF TREATMENT SHOWED A SIGNIFICANT INCREASE IN FIRST DEGREE AV-BLOCKS AND ABNOMALITIES OF REPOLARIZATION UNDER IMIPRAMINE BUT A SIGNIFICANT REDUCTION OF SUCH PATHOLOGICAL FINDINGS UNDER TREATMENT WITH HYPERICUM EXTRACT. IT SHOULD BE EMPHASIZED THAT THIS FAVORABLE FEATURE OF SAFE CARDIAC ACTIVITY WAS ACHIEVED WITH 18000 MG OF HYPERICUM EXTRACT. |
| Dose amount | 1.8 GM |
| Number | 1 |
| Qualitative result | INACTIVE |
| Animal | HUMAN ADULT |
| Per unit | DAY |
| Dose expression | DOSE |
| Extract | HYDRO-ALCOHOLIC EXT |
| Gender | GIVEN TO BOTH SEXES |