Experiment 387900
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Hypericum perforatum (CLUSIACEAE) |
| Citation | WHEATLEY,D:. (1997). LI 160, AN EXTRACT OF ST.JOHN'S WORT, VERSUS AMITRIPTYLINE IN MILDLY OT MODERATELY DEPRESSED OUTPATIENTS - A CONTROLLED 6-WEEK CLINICAL TRIAL.. 30() |
| Amount utilized | |
| Compound isolated | |
| Disease | A DOUBLE-BLIND RANDOMIZED MULTICENTER STUDY WAS PERFORMED TO EVALUATE THE EFFICACY, SAFETY AND TOLERABILITY OF 900 MG/DAY OF A HYDROALCOHOLIC EXTRACT OF THE HERB COMPARED WITH 75 MG AMITRIPTYLINE. AFTER ONE WEEK PLACEBO RUV-IN PHASE, 156 SUBJECT WERE TREATED WITH 300 MG OF THE EXTRACT OF 25 MG OF AMITRIPTYLINE THREE TIMES DAILY FOR 6 WEEKS. THE SUBJECTS WERE ASSESSED AT BASELINE AND THEN AT 1, 2, 4 AND 6 WEEKS AFTER TREATMENT ACORDING TO THE HAMILTON DEPRESSION SCALE (DAMD), MONTGOMERT -ASBERG RATING SCALE FOR DEPARESSION (MADRS), AND CLINICAL GLOBAL IMPRESSIONS SCALE (CGI). CHANGES IN THE HAMD FROM BASELINE TO 6 WEEKS: 20 TO 10 IN THE EXTRACT TREATED PATIENTS, AND 21 TO 6 IN THE AMITRIPTYLINE TREATED PATIENTS (P<0.05). CHANGES IN THE MADRS, 27 TO 13 IN THE EXTRACT TREATED PATIENTS, AND 26 TO 6.5 IN THE AMITRIPTYLINE TREATED PATIENTS (P<0.05). SIMILAR SCORES IN THE CGI SCALE WERE OBSERVED IN BOTH GROUPS. |
| Dose amount | 900.0 MG |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | DAY |
| Dose expression | DOSE |
| Extract | HYDRO-ALCOHOLIC EXT |
| Gender | GIVEN TO BOTH SEXES |